Many unique challenges are associated with the development of robust catalytic transformations that can be applied to the multi-kilogram scale synthesis of pharmaceutical intermediates. At BMS, our approach to the development of scalable catalytic processes relies upon the strategic application of high-throughput experimentation (HTE), along multi-variate design of experiments (DoE) and kinetic and mechanistic studies. This talk will describe our group’s research philosophy and capabilities, and highlight some of our recent learnings though several case studies. Ongoing efforts to expand our research capabilities by exploiting base metals and photoredox catalysis to build the molecules that will become the medicines of tomorrow will also be discussed.

Applications of HTE to the discovery and development of robust, scalable catalytic transformations for the synthesis of complex pharmaceutical intermediates

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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