Recent studies associate the use of xenobiotics with modulations in gut microbiome. Metformin, for example, is a first-line therapeutic treatment for Type-2 Diabetes (T2D) whose mechanism of action for its antidiabetic phenomenon can occur through modulation of gut microbiome. To understand the intricacy of the modulation, we are looking into the effect of this drug on individual members of the gut microbiome. Integration of multi-platform techniques like growth curve analysis and flow cytometry will help us glean into the intricacies of the microbiome dynamics after exposure xenobiotic like metformin. By deciphering the direct effect of the drug metformin on an isolated component of the microbiome community, Prevotella copri. Potential toxicity of xenobiotics to the microbiota were observed as the growth of Gram-negative bacteria, P. copri was significantly altered once exposed to both, metformin and tetracycline treatment. The capacity for the bacteria to grow under the dose of the antidiabetic was restricted in a dose dependent manner. Therefore, underscoring potential modulations and implications of metformin on gut microbiome homeostasis contributes to potential risk assessment, drug discovery and toxicity factors.

Xenobiotics and microbiota physiology and metabolism

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.