The use of theranostic agents in nuclear medicine allow for patient-specific strategies that combine diagnosis and therapy. Imaging with chemically identical diagnostic and therapeutic agents is ideal as the chemical structure of the compound remains the same. Therefore, the development of matched radionuclide pairs for use in receptor targeted therapies and imaging is an emerging area of research. One promising radionuclide pair is the positron-emitting 43Sc (t1/2 = 3.90 h) and beta-emitting 47Sc (t1/2 = 3.35 d). In particular, production routes for 47Sc are underexplored. To determine the feasibility of producing 43,47Sc using enriched titanium targets via the 46Ti(p,a)43Sc and 50Ti(p,a)47Sc reactions, work was carried out to investigate yield, targetry, and purification chemistry with a focus on the production of 47Sc. Scandium-47 was produced by the 50Ti(p,α)47Sc reaction, using pressed powder enriched titanium oxide targets prepared in house. Targets were contained in a coin style target holder and irradiated on a TR-24 cyclotron at the University of Alabama at Birmingham. Irradiated targets were digested with NH4HF2 and then dissolved in heated HCl. After digestion, 47Sc was isolated and purified by cation exchange chromatography using branched DGA resin (N,N,N’,N’-tetrakis-2-ethylhexyl-diglycolamide) with a mean recovery of 90 ± 3%. Recovery of the enriched titanium target material was &gt;95%. 47Sc was used to synthesize [47Sc]PSMA-617 to illustrate the utility of the produced radioisotope. Data from these experiments show that 43Sc/47Sc can be produced, separated, and purified from enriched Ti targets. These results support further investigation of 43Sc/47Sc production and radiochemisty studies.

Production and radiochemistry of 43Sc and 47Sc for imaging and radiotherapy

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.