Amphiphilic grafted nanoparticles (AGNs) can function as microenvironments to facilitate dispersion of oil in aqueous media. Previous work from our group has outlined the synthesis of a block copolymer of poly(caprolactone)-b-poly(oligo (ethylene glycol) mono-methyl ether methacrylate) (PCL-b-POEGMA) from SiO2 nanoparticle cores. The research herein aims to replicate the “graft from” synthesis using crosslinked 10-100 μm maltitol-NP cores. Surface-initiated ring opening polymerization (SIROP) of ε-caprolactone was carried out at room temperature, successfully grafting the hydrophobic block of our AGN. Post-polymerization functionalization of poly(caprolactone) with α-bromoisobutyryl bromide provides the necessary scaffold for subsequent surface-initiated atom transfer radical polymerization (SI-ATRP). POEGMA, generated from the SI-ATRP reaction, functions as a bulky hydrophilic block that facilitates dispersion in aqueous conditions. To optimize effectiveness of the AGNs, it is the goal to maximize the hydrophobic volume and minimize the hydrophilic block thickness such that the particles maintain their ability to rapidly sequester any lipophilic compounds. Through collaborations, we can better understand the effectiveness of these particles and how they influence the environment.

Synthesis of amphiphilic grafted nanoparticles as a bio-friendly alternative for hydrophobic molecule encapsulation

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.