As our ongoing interest, we have reported tandem processes to generate diverse keto-alkynes and 1,6-enyne hydrocarbons. These high-value substrates can undergo ring-opening fragmentation reactions to deliver valuable building blocks for many annulation and cycloisomerizaiton strategies To obtain carbocycles and of natural product target structures. We have been developing our methodologies to access functionalized 1,6-diyne hydrocarbons that are otherwise hard to prepare.

Synthesis of differentially substituted diynes via tandem nucleophilic addition/fragmentation pathways

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.