Microwave-assisted gold catalysis has been employed to promote Friedel–Crafts-like reactions of benzylic alcohols. Functional 1,1-diarylalkanes were prepared in good to excellent yields under mild conditions. The transformation showed good reaction scope, tolerating a range of cyclic and acyclic benzylic alcohols containing electron rich and electron deficient functional groups. Application of this gold catalysis methodology was also used to prepare a series of substituted fluorenes and pharmaceutically relevant compounds. Kinetic isotope effect and mechanistic considerations will be also discussed.

Gold-catalyzed Friedel–Crafts-like reaction of benzylic alcohols to afford 1,1-diarylalkanes

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.