While the aldol addition has proved essential in chemical synthesis, no general solution exists for the direct catalytic enantio- and diastereoselective aldol reaction.  Herein, we present a perfectly atom-economical approach to such a process, employing easily accessed and synthetically versatile ynone nucleophiles.

Catalytic enantio- and diastereoselective aldol addition of ynone nucleophiles

239th National Meeting (2010)

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