The polyurethane(PU) tubing surfaces were covalently bound with 5, 5-dimethyl hydantoin (DMH), an N-halamine precursor, using MDI as a coupling agent under one step in site surface modification. The reactions were confirmed by attenuated total reflectance infrared. Upon bleach treatment, the DMH moieties on the PU tubing surfaces were transformed into N-halamine, providing powerful, durable, and rechargeable antimicrobial activities against Staphylococcus aureus (S. aureus, Gram-positive), Escherichia coli (E. coli, Gram-negative), methicillin-resistant staphylococcus aureus (MRSA, drug resistant Gram-positive bacteria), vancomycin-resistant enterococcus (VRE, drug resistant Gram-positive bacteria), and Candida albicans (C. ablicans, fungi). SEM studies demonstrated that the N-halamine-based PU tubing could effectively prevent the formation of bacterial and fungal biofilms. These encouraging results point to great potentials of the new N-halamine-based PU tubing for a wide range of related medical, environmental, and industrial applications to controlling the formation ofbiofilms. Keywords: Antimicrobial, Biofilm-controlling, N-halamine, Chlorination, Rechargeable, Polyurethane, Tubing.

N-halamine-based rechargeable and long-term antimicrobial polyurethane tubing

243rd National Meeting (2012)

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