Stroke has reached epidemic levels globally; over 15 million people suffer from stroke worldwide annually. Currently, the available options for the treatment of stroke-related brain damage are limited. In our efforts to discover compounds with neuroprotective properties as therapies for ischemic stroke, we recognized that structurally diverse natural neuroprotective molecules (e.g. limonoids, cardiac glycosides & estrogen-like compounds) shared a common structural motif. In order to determine the structural elements required for potent neuroprotective activity, we synthesized the core structure and its analogues and evaluated their neuroprotective activity. Some of the analogues showed dose-dependent neuroprotective activity at micromolar concentration in terms of neuronal survival against hydrogen peroxide induced cell death in vitro. The results will be useful in establishing the structure-activity relationship requirements for developing more potent neuroprotective agents.

Neuroprotective activities of a common structural motif in neuroprotective natural products

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.