A set of mono- and diamides were prepared and tested as potential drugs for maintaining the pluripotency of stem cells. The drugs were designed to act as a competitive inhibitor of the docking domain of the protein of interest and block specific protein-protein interactions. The small organic molecule drugs were then tested in an assay that determines the amount of accumulated � -catenin. There is an established connection between �-catenin concentration and pluripotency and therefore it is reasonable to assume that use of drugs that lead to high concentrations of � -catenin, are promising leads for maintaining stem cells in a pluripotent state. The studies show that certain monamides have interesting, yet unexpected results in the biological studies. Some of the drugs were also tested in controlled differentiation experiments, giving promising results. The design, synthesis, and purification of the small molecule drugs as well as the results from some biological studies will be presented.

Design and synthesis of mono- and diamides as potential drugs for maintaining stem cell pluripotency

243rd National Meeting (2012)

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