Sixteen new analogues of DDB were synthesized and evaluated for their cancer preventive activity by an in vitro EBA-EA activation assay and an in vivo mouse-skin carcinogenesis test. Compound 19   exhibited remarkable cancer preventive effect in vitro and in vivo, which suggested that 19  is likely to be a valuable candidate as a cancer preventive agent or as a lead for the development of new antitumor promoter drugs.

Novel dimethyl dicarboxylate biphenyl (DDB) analogs as potent cancer chemopreventive agents

243rd National Meeting (2012)

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