Tetracyclic backbones with hetero atoms are important scaffolds for different  biological targets. These compounds have been used as anti-microbial or anti- cancer agents. One important target for cancer therapy is the topoisomerase  enzyme. In this study we aimed to synthesize a series of novel tetracyclic  indenoquinoline derivatives and evaluate their biological activity through in vitro cytotoxicity studies on  cancer cells. Preliminary results have shown that indenoquinoline  backbone posses anticancer activity that prompted us to further examine this  backbone for cancer therapy. To this end, we have synthesized a series of tetracyclic indenoquinoline  derivatives and analyzed them using NMR, mass and infrared spectroscopy. Anticancer activity of these compounds is currently being investigated in cells. Through rational design based synthesis and  characterization of tetracyclic indenoquinoline derivatives we hope to develop  novel therapeutic interventions for cancer.

Synthesis of novel nitrogenous tetracyclic compounds as potential anticancer agents

243rd National Meeting (2012)

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