A simple, sensitive and reliable electroanalytical method was developed for the investigation and analytical trace determination of Ciprofloxacin (CIP) antibiotic in pure and drug formulation forms. The attractive voltammetric performance of CIP antibiotic was characterized at a new composite material, glassy carbon paste. The electroanalytical technique used was square wave stripping voltammetry. Factors influencing the trace measurements of CIP at glassy carbon paste composite electrode surfaces were assessed. Useful analytically concentration dependence, extending from 0.05 to 10 �g/mL, is obtained, along with a detection limit of 10 ng/mL. Application of the developed method to biological samples e.g. human urine was assessed. The method was applied to different commercial pharmaceutical products (Quinox and Emicipro) with very good recoveries. The new developed detection method is highly reproducible with a relative standard deviation of 0.189 for a series of measurements of seven different CIP samples and at a new electrode surface every time.

Analytical determination of trace ciprofloxacin antibiotic concentrations in pure and drug formulation forms

243rd National Meeting (2012)

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