Oxidative carbon�carbon bond forming reactions are powerful transformations, which when applied strategically for the construction of complex molecules, can provide concise and efficient syntheses.  This research focuses on developing new methods for the formation of commonly occurring motifs in nature: namely that of 1,4-diketones and their potential to construct other classes of molecules such as linked quinones/phenols and benzofurans.  By utilizing an enone aryl surrogate system, oxidative dimerization has led to a new method for biaryl synthesis.  The enantioselective synthesis of various axially chiral biaryl compounds has been developed utilizing a templated chirality transfer approach in the formation of highly substituted single atropisomers.  This methodology has been applied to the concise total synthesis of bismurrayquinone A.

Formal oxidative arylation strategies: Synthesis of enantiopure biaryls

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.