Various synthetic protocols have been developed recently for the preparation of trifluoromethylated arenes. In contrast, CF2H-containing aromatic compounds are almost exclusively achieved through deoxofluorinations of aromatic aldehydes. As a continuation of our synthetic efforts in organofluorine chemistry, a facile preparative method has been explored towards difluoromethylated aromatics from readily available trifluoromethyl arenes. Mediated by Mg(0) under mild conditions, a series of bis(trifluoromethyl)aromatics can be selectively converted into the corresponding difluoromethyl products by the present protocol in practical yields.

Selective preparation of difluoromethyl aromatics via Mg(0)-mediated C-F activation of aromatic trifluoromethyl compounds

243rd National Meeting (2012)

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