Finding mild, chemoselective, and general conditions for the reduction of amides is of great importance for pharmaceutical chemistry, as this could serve as a template for the direct formation of compounds possessing basic nitrogens. To address this problematic, the activation of secondary and tertiary amides to a more reactive intermediate can be performed with triflic anhydride, which was shown to react with weak hydride donors to result in a controlled reduction with high efficiency and chemoselectivity.

Controlled and chemoselective reductions of secondary and tertiary amides: Versatile applications of Hantzsch ester hydride and Et<sub>3</sub>SiH as reducing agents

243rd National Meeting (2012)

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Controlled and chemoselective reductions of secondary and tertiary amides: Versatile applications of Hantzsch ester hydride and Et3SiH as reducing agents

Controlled and chemoselective reductions of secondary and tertiary amides: Versatile applications of Hantzsch ester hydride and Et₃SiH as reducing agents