We have recently developed new TEMPO-PEG-RGDs conjugates, and have quantitatively examined their antithrombotic and antioxidant capabilities. These compounds were therapeutically beneficial when characterized in both in vitro platelet aggregation assays and a rat model of arterial thrombosis. Moreover, these compounds demonstrated significant protection from organ damage in a rat model of ischemia/reperfusion.  Our data indicate that TEMPO-PEG-RGDs represent a new class of adjuvants with therapeutic efficacy in acute and transient ischemic damage.

Novel TEMPO-PEG-RGDs conjugates remediate tissue damage induced by acute limb ischemia/reperfusion

243rd National Meeting (2012)

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