Fluorescent sensors which sense ions or neutral analytes demonstrate their potential roles in a variety of fields, such as biological sensors, environmental sensors, molecular devices, nerve gas sensor, etc. The selective binding of chemical species upon molecular recognition can lead to large perturbations in the host environment, particularly when the guest is ionic. These sensors based on the analyte-induced changes in fluorescence are particularly attractive due to their simplicity and in vivo/in vitro imaging. Various fluorophores such as rhodamine, pyrene, and naphthalimide derivatives are used as a probe for many ions or biological molecules. Thus, we designed various fluorescent chemosensors containing these fluorophores and those sensors showed excellent selectivity for certain analytes. For example, Rhodamine derivative was reported as a HOCl sensor which emits strong fluorescence when it reacts with the HOCl. In addition, pyrene based sensors were designed as probes for lysine. Gold ion sensor based on a naphthalimide derivative was designed and showed high selectivity toward Au3+ ions. Some of these sensors were successfully applied in cell imaging showing their potentials for biological applications.

New fluorescent sensors based on various fluorophores and their biological applications

243rd National Meeting (2012)

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