As states move quickly to put legislation in place banning the sale and use of synthetic cannabinoids, the need for a sensitive, noninvasive method for the detection of these compounds increases. Because of the nature of these substances, they occur in minute quantities in the aqueous saliva matrix. This research evaluates the use of solid phase micro-extraction gas chromatography mass spectrometry (SPME-GC-MS) to detect and positively identify JWH-018 and JWH-073 present in saliva. The isolation of the analytes of interest and viability of this approach to detect low levels of these substances will be discussed.

Method development for the isolation and detection of synthetic cannabinoids in saliva

243rd National Meeting (2012)

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