N-alkyl urea peptoids are oligomeric biomimetic molecules that can be thought of as hybrids between oligoureas, N-acyl glycines (peptoids) and 2-? peptides.  By virtue of their iterative synthesis strategy a wide variety of functional side chains can be incorporated and the urea functionality facilitates hydrogen bonding leading to self-assembly properties.  This presentation will describe the self assembly of N-alky urea peptoid oligomers and polymers into fiber-like assemblies.  We have characterized the self-assembly using a variety of NMR techniques including NOE correlation spectroscopy and deuterium exchange experiments.  Finally, we have conjugated the hydrophilic and biocompatible macromolecule polyethylene glycol (PEG) to the N-alkyl urea peptoid oligomer and shown that the self-assembly is retained

Self-assembly of N-alkyl urea peptoid polymers and oligomers

243rd National Meeting (2012)

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