Plastic antibodies, synthetic polymer nanoparticles (NPs) capable of binding to specific biomacromolecules, are of significant interest as stable and inexpensive substitutes for natural ligands such as antibodies. Recently,  strategies to prepare plastic antibodies have been reported. For example, plastic antibodies for toxic peptides have been prepared thru optimizing combination of functional monomers. Binding affinity and specificity of the NPs were further improved by the molecular imprinting or affinity purification process. However, strategies to design binding kinetics of synthetic nanomaterials have not been reported. In this research, we investigated relationship between polymer density of plastic antibodies and the kinetics of target binding.

Influence of polymer density of plastic antibodies on target binding kinetics

243rd National Meeting (2012)

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