Glycosylation is one of the most important reactions in biological systems due to its use in the synthesis of pharmaceuticals. Naturally occurring C-glycosylflavonoids exhibit antiviral, cytotoxic, hypotensive and DNA binding activities. Moreover, C-glycosylflavonoids can inhibit the proliferation of liver cancer cells, act as free-radical scavengers, and chelate to metal ions forming metal-ion complexes. We sought to investigate and optimize the glycosylation of various flavone precursors with various Lewis acids. Additionally, the binding affinity of non- and C-glycosylated compounds with bovine serum albumin, a crucial protein for regulating the colloidal osmotic pressure of blood, will be investigated to probe the structural determinants of binding.

Synthesis of <i>C</i>-glycosyl compounds and the study of its interaction with the plasma protein bovine serum albumin

243rd National Meeting (2012)

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Synthesis of C-glycosyl compounds and the study of its interaction with the plasma protein bovine serum albumin