Four complexes of the type [9]aneS3Ru(ATSC)Cl]Cl where ATSC = 9-anthraldehyde thiosemicarbazones with a N3-alkyl (H, CH-3, C2H5 or C6H5) substituent were synthesized. The complexes bind to DNA moderately with binding constants ranging from 3.21 x 104 � 1.27 x 105 M-1. Electronic absorption spectral analysis of the reaction of the complexes with model proteins did suggest that they can bind to the proteins. In addition, the complexes bind to human serum albumin with the binding constants on the order of 104 M-1. We have investigated the cytotoxicity of the complexes against 22Rv1 (human prostate) cells, HCT-116 (human colorectal) and MCF-7 (human breast) cancer cell lines along with a non-tumorigenic CCD-18Co (human colon fibroblasts) cell line. Against the 22Rv1 cell line the complex bearing a phenyl group on N3 was the most active. They show good antibacterial profiles against gram-positive bacterial strains but showed no activity against the gram-negative strains we studied.

Synthesis, biophysical reactivity and medicinal evaluation of a series of half-sandwich ruthenium complexes with a 1,4,7-trithiacyclononane face-cap

243rd National Meeting (2012)

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