The objective of this study is to develop an innovative methodology to control the growth of microbes in chronic wounds. Chronic wounds are confined infections which are regarded as an epidemic health problem. The cause of chronic wounds is due to the existence of biofilms. Biofilms are considered ubiquitous in the natural world. Bacterial biofilms have been observed to be extremely heterogeneous, both structurally and with regard to the physiology of the bacterial cells within them. The prevailing conceptual model depicts bacterial biofilms as being made up of microcolonies, which serve as the basic unit of the greater biofilm structure. A major concern is the frequently observed development of resistance to antimicrobial compounds and even host's own immune system. The goal of present study aimed to develop a novel drug-containing nanoparticulated systemin vitrofor penetrating biofilm and therefore reach the wound.

Nanoencapsulated drug delivery for biofilms

243rd National Meeting (2012)

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