The high in vivo stability of long-circulating liposomes leads to slow drug release that compromises drug bioavailability and efficacy. Lysolipids have been incorporated into liposomes to design temperature-sensitive systems known as low temperature sensitive liposomes (LTSL). These exhibit reduced phase transition temperature that allows for rapid drug release under hyperthermia conditions. Here, we report the engineering of hybrid vesicular systems between LTSL and metallic nanoparticles embedded within the lipid bilayer as a promising strategy to gain more control of drug release capabilities on external stimulus. Gold and superparamagnetic iron oxide nanoparticles were successfully incorporated into the LTSL. The incorporation of the metallic nanoparticles within the lipid bilayer was optimized using three techniques: lipid film hydration, reverse phase evaporation and lipid film-reverse phase evaporation methods. Doxorubicin was able to be encapsulated at high efficiencies in the liposome-nanoparticle hybrids and release profiles were compared at 37�C and 42�C. The incorporation of nanoparticles within the lipid bilayer interfered with the drug release properties of LTSL and offered higher stability at 37�C without affecting release at 42�C.

Thermosensitive liposome stabilization with nanoparticle bilayer incorporation for controlled drug delivery

243rd National Meeting (2012)

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