Here in this research, we would like to discuss about the effect of molecular movement of materials surface on the biological responses. In order to develop mobile bio-interfaces, we designed polyrotaxane (PRX) based block copolymers containing hydrophobic anchoring group. Surface characteristics was carried out by using XPS and contact angle hysteresis analysis. As a result, prepared PRX surface shows dynamic changes on its hydrophilicity along with the dry-wet environmental changes which is possibly due to the molecular movement. The amount of fibrinogen adsorption and the conformation change was estimated by QCM-D and ELISA test. As a result, adsorbed fibrinogen shows high value of dissipation factor which indicates that fibrinogen molecules are weakly interact with PRX surface, and this contributed to the moderated conformation change. The resulting PRX surface shows moderated platelet adhesion and increased endothelial cell adhesion which indicates that the mobile signal can regulate a specific biological responses.

Biological responses on the dynamic surfaces prepared by supramolecular block copolymers

243rd National Meeting (2012)

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