The preparation of poly(2-oxazoline)s by a two-step surface-initiated polymerization, self-initiated photografting and photopolymerization with surface-initiated living cationic ring-opening polymerization (SIPGP-LCROP), allows the design of complex polymer brush architectures of POx on diamond electrodes suitable for the incorporation of a broad variety of chemical functions. It was demonstrated by fluorescence microscopy (GFP) and colorimetric essays (HRP) that coupled proteins (GFP and HRP) maintain their native activity after immobilization. The (bio)functionalization of diamond via patterned polymer brushes based on POx enable the study of surface interactions in biological media with the precise variation of the surface topography, local biomolecule concentration and its accessibility.

Biofunctionalization of patterned poly(2-oxazoline) bottle-brush-brushes on diamond

243rd National Meeting (2012)

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