Numerous clinical trials and intensive research efforts have indicated that continuous monitoring of multiple bio-analytes holds great potential to provide an early indication of several body disorders.   This has sprung up intensive R&D efforts towards developing faster and cheaper diagnostic platforms suitable to readily detect various biomarkers, metabolites and nucleic acid bio-analytes.  While various bio-assay technologies currently provide the means to obtain a snapshot measurement of these bio-analytes, the development of implantable sensor platforms could potentially provide the means to obtain long-term trends, capable to foresee impending disorders, independent of subject's physiology. To this end, over the past decade, the University of Connecticut (UCONN) team together with its spin-off corporation, Biorasis Inc., has been developing a needle-implantable, miniaturized (0.5 x 0.5 x 5 mm), totally implantable biosensor capable of continuously monitoring various metabolites for more than 3 months.Our approach is based on: (i) extreme miniaturization for minimal tissue damage; (ii) localized release of various tissue response modifiers to afford effective inflammation control and fibrosis suppression along with neo-angiogenesis; (iii) means to account for unwanted sensor drifts over extended periods of operation; and (iv) substantial improvement in sensor performance via multi-sensing element architecture.Our presentation will present the state of the art in metabolic sensing, using electrochemical approaches, together with the ability to translate such implantable platform towards continuous detection of more complex bio-analytes.  Emphasis will be given in futuristic sensing technologies and the critical requirements one has to tackle to achieve reliable monitoring inter-related bio-analytes.

Miniaturized, needle implantable, wireless biosensor for continuous monitoring of multiple bio-analytes

243rd National Meeting (2012)

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