The Thomsen Friedenreich antigen is a tumor associated carbohydrate antigen (TACA) that is implicated in the processes of tumor invasion, metastasis and immune recognition. It is an important disaccharide used in many previous anticancer immunotherapies and vaccine preparations. We have synthesized TF antigen in various guises and used them to coat nanoparticles. These particles were evaluated as antiadhesive agents to prevent tumor metastasis and as vaccine platforms to promote an immune response to TF-bearing glycopeptides. Recent progress on these fronts will be discussed.

Various nano-guises of the TF antigen for anticancer therapy

243rd National Meeting (2012)

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