Incorporation of cultured cells with polymer scaffolds can be used as biological substitutes for tissue implantations. The protein adsorption on the polymer surface is a crucial point for the attachment of the cell. Aliphatic polyesters such as polycaprolactone (PCL) and poly(3-hydroxybutyric acid-co-3-hydroxyvalerate) (PHBV) have suitable characteristics for usage in medical applications. The blend structure of the two polymers are affected by the blend compositions as well as by the fabrication method, we wish to the effectiveness of the blend composition on the physical and the physico-chemical properties of the solvent-cast PCL/PHBV films. Such variations may lead to different adsorption behavior of proteins, which, in turn, could lead to different response of the cultured cells. The films were characterized for their degree of crystallinity, miscibility, hydrophobicity, and surface morphology.  The ability to support the cell viability was investigated by protein adsorption test, indirect cytotoxicity test, and cell attachment and proliferation test.

Effect of blend compositions on physical and physico-chemistry of solvent-cast polycaprolactone/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) blend films

243rd National Meeting (2012)

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