A variety of methods for the synthesis of 5-membered N,O-heterocyclic benzoxazole rings were reported, in which various toxic chemical reagents were used in the reactions. To avoid and reduce the pollutions from the usage of toxic chemicals, we report a new synthetic method in a green pathway, which utilizing intramolecular anodic coupling to observe the benzoxazole ring.  Through screening various substituents and reaction conditions, efficient anodic cyclizations for the synthesis of benzoxazole derivatives were observed. Mechanism and CV studies will be discussed.

Novel anodic coupling in the synthesis of benzoxazole derivetives with CV and mechanism studies

243rd National Meeting (2012)

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