Manipulation of surface nanotopology has been a growing trend in efforts to enhance tissue regeneration, repair, and biocompatibility. Understanding the interactions of biomolecules with nanoengineered surfaces is vital to assess the safety and efficacy of devices that incorporate these structures. We present our research on protein adsorption dynamics on nanopatterned block copolymers.  Modified and functionalized polymers were processed to produce various nanopatterned films of different nanotopologies, morphologies, and domain sizes, and these were characterized using contact angle measurements and atomic force microscopy (AFM). Protein (fibrinogen, albumin, cytochrome C, immunoglobulin G) adsorption experiments were conducted under static and dynamic conditions with a quartz crystal microbalance with dissipation (QCM-D) and AFM. Results indicate that the nano-morphology and biochemical environment impact adsorption dynamics.

Protein adsorption on nanopatterned block copolymers

244th National Meeting (2012)

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