The synthesis and characterization of dye labeled carboxylic acid coated silica nanoparticles were investigated. A monolayer of carboxylic acid coated silica nanoparticles with fluorescent tags was prepared by a coupling reaction with dye molecules, followed by a ring opening reaction with succinic anhydride. Poly(methacrylic acid) grafted silica nanoparticles were prepared by the treatment of poly(tert-butyl methacrylate) grafted silica nanoparticles with excess of AIBN and subsequent deprotection of the tert-butyl ester groups. TEM images showed that the poly(methacrylic acid) grafted silica nanoparticles were well dispersed with diameters of the individual nanoparticles ~ 30 nm. The binding of antibiotics to nanoparticles enhances their antimicrobial activities, and represents a potential tool for enhancing the effectiveness of existing antibiotics.

Synthesis and characterization of dye-labeled carboxylic acid coated silica nanoparticles for drug delivery applications

244th National Meeting (2012)

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