Branched poly(2-hydroxpropyl methacrylate), synthesised by ATRP with an ethylene glycol dimethacrylate brancher, has been synthesised at varying primary chain lengths leading to very high molecular weight macromolecules. When subjected to nanoprecipitation, analogous linear polymers formed unstable nanoparticles however branched polymers produced stable particles with tunable sizes. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/240nm/uploads/46523_figure_1.jpg' alt='' /> This is the first report of branched synthetic polymers undergoing nanoprecipitation and studies have shown the stability appears to be derived from the complex architecture.

Architecture-driven aqueous stability of hydrophobic, branched polymer nanoparticles prepared by rapid nanoprecipitation

244th National Meeting (2012)

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