Bioorthogonal reactions, in which the coupling partners react selectively without interference with other biological functionalities, are important tools for chemical biology research. Our group is interested in developing novel platforms enabling both bioconjugation and peptide coupling. We recently discovered a proline-based phosphine template which could allow fast Staudinger ligation with azide-containing substrates. It could also be used for the reductive ligation of S-nitrosothiols. In this presentation, we will report some detailed results of these reactions including kinetics, pH dependence, reaction generality, etc.

Proline based phosphine template for bioorthogonal reactions

244th National Meeting (2012)

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