1,2,4-Oxadiazole is a versatile ring system that has found application in medicinal chemistry as a pharmacophore, as a component in drug molecules including Perebron, and Libexin, in material science in the formulation of ionic liquids, liquid crystals, and OLEDs (organic light emitting diodes). ANRORC reactions are valuable synthetic tools in ring transformations of heterocyclic systems. In the present work, we focus on a novel ANRORC approach to synthesize 2,4-substituted quinazolines and 4H-benzo[e][1,3]thiazine from 1,2,4-oxadiazoles in a single transformation. 

Preparation of benzoxazines, quinazolines, and 4H-benzo[e][1,3]thiazine via ANRORC rearrangements of 1,2,4-oxadiazoles

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.