High intensity ultrasound has been used to prepare hollow polymeric microspheres with potential drug delivery applications. The emulsification effects of ultrasound together with the radicals formed by cavitation combine in a facile one pot procedure to yield hollow microspheres, consisting of a disulfide cross linked shell encapsulating a gaseous or liquid core.This paper will describe the synthesis and characterisation of diblock copolymers of a thiol modified poly(methacrylic acid) block with a responsive segment; poly(N-isopropylacrylamide) and their use in the formation of novel, temperature responsive hollow microspheres. Some examples of encapsulation and release of hydrophilic and lipophilic molecules, including drugs, polymers and salts will be described.

Hollow polymeric microspheres for temperature responsive delivery

244th National Meeting (2012)

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