Application of fullerenes and their biocompatibility studies suffer from lack of size control; thus systematic size-dependent studies on fullerenes had not been realized. This study presents a robust protocol that prepares size-tunable and colloidally stable aqueous fullerenes with biocompatible non-ionic polymers. Size-uniformity was achieved through a mechanochemical process with a range of polymer-fullerene ratio. The minimum reproducible sizes achieved were 58.8�5.6 and 61.8�5.6 nm for nC60s and nC70s, respectively. Enhanced stability was observed even at highly saline or biologically relevant media conditions. Stability and cluster size results are described with polymer conformation on fullerene surfaces, providing steric repulsion. Molecular dynamic simulation studies validated the polymer conformation based on cluster size and relative curvature of nC60s and nC70s. Such biocompatible fullerene suspensions can facilitate not only medicinal and biological applications but also will aid in mechanistic evaluation of their size-dependent environmental and toxicological behavior.

Size tuned aqueous nC<sub>60</sub>s and nC<sub>70</sub>s stabilized with biocompatible surface coatings

245th National Meeting (2013)

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Size tuned aqueous nC60s and nC70s stabilized with biocompatible surface coatings

Size tuned aqueous nC₆₀s and nC₇₀s stabilized with biocompatible surface coatings