The biomolecules presented in a typical biochemistry or organic chemistry course are often large and difficult to visualize. However, it is important to understand the size and topology of these macromolecules. We believe there is significant value to be gained by using accurate images of the organic molecules. We also want students to understand the organic chemistry that is related to the enzymes, nucleic acids, lipids, and carbohydrates that are discussed in a standard biochemistry course. In order to accurately represent the biomolecules, we have used crystal structures from the protein data bank. We have used simple MM2 type calculations to represent the chemical changes that occur for the metabolic processes. Our software also allows the student to manipulate both the pdb structures and the calculated metabolic process in 3D space. This opportunity is important for the learning process. The teaching tool we have developed is called Bio-Organic Reaction Animations (BioORA). It is available online at no cost to the user. We will discuss the content of the program and our assessment of its impact on learning.

Modeling of biomolecules for organic and biochemistry courses

245th National Meeting (2013)

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