Chiral porous metal-organic frameworks (MOFs) can be rationally constructed by connecting metal nodes with chiral bridging ligands bearing orthogonal catalytic functionalities. These chiral MOFs represent ideal heterogeneous asymmetric catalysts in which both the catalytic sites and their secondary environments are identical throughout the solid. We have recently synthesized a family of highly stable and porous MOFs based on the privileged asymmetric ligand, 2,2'-bis-1,1'-binaphthyl (BINAP). Using various post-synthetic functionalization methods, we have prepared various active catalysts for the hydrogenation of alkenes, beta-keto esters, and ketones. The MOF catalysts not only gave high stereoselectivities but also are recyclable and reusable. The scope of this MOF catalyst platform will also be discussed.

Highly stable and porous metal-organic frameworks for asymmetric catalysis

245th National Meeting (2013)

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