Functional vaccine coatings were assembled on the surface of poly(lactide-co-glycolide) microneedles using layer-by-layer deposition of degradable poly(beta-amino-esters) with lipid nanocapsules containing protein antigen and immune-stimulatory adjuvants.  This process allowed controllable encapsulation of intact nanocapsules into microneedle-based surface-films.  Application of vaccine-coated-microneedles in vivo gave rapid implantation of films into the skin forming depots to sustain vaccine release through poly(beta-amino-ester) degradation.  Microneedle-vaccines generated localized influx/activation of immune cells, cell uptake of vaccine-nanocapsules, and induced enhanced antigen-specific antibody responses.

Layer-by-layer assembly of lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery

245th National Meeting (2013)

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