A premier example of Click chemistry (high-yield, thermodynamically driven reactions which utilize simple molecular building blocks to create more complex species through the formation of new heteroatom bonds) is based on the Huisgen 1,3-dipolar cycloaddition of azides to alkynes, in which the reaction is very effectively catalyzed by copper.  While this reaction motif is quite prolific, analogous cycloaddition reactions utilizing azides or acetylides originating within the coordination sphere of a metal are much less prevalent.  Our synthesis of 1,5-bis-triphenylphosphinegold(I) 1,2,3-triazolate via an unprecedented inorganic click (iClick) reaction between a gold-azide and a gold-acetylide marks the first example in the literature in which both the azide and acetylide participating in the cycloaddition reaction are within metal coordination spheres.  Current work highlighting homonuclear gold(I) iClick reactions is demonstrated, as well as the extension to heteronuclear iClick reaction between gold(I) and groups 9 and 10 transition metals.

Expanding inorganic click (<i>iClick</i>): Cycloadditions between metal-azides and metal-acetylides

245th National Meeting (2013)

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Expanding inorganic click (iClick): Cycloadditions between metal-azides and metal-acetylides