Supramolecular nanosponges prepared from bottom up approaches are optimized towards the anticpated release rate and the structure property relationship is discussed. Crosslinking density, polyester and polycabonate backbone length are one of the measures that determines the release kinetic. Integrated functional groups enable practical conjugation of targeting units and dyes. To solubilize and stabilize protein therapeutics in a grafting-from approach semibranched polyglycidols were grown to form in situ 'PEG' like surface shells to function as advanced pegylations.

Release dynamics in nanosponge materials and the formation of "peg" like polyglycidols

245th National Meeting (2013)

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