Schiff bases containing a pyridine N-oxide moiety attract much less attention from coordination chemists than their pyridine analogues or Schiff bases derived from salicylaldehyde. The main reason is commercial inaccessibility of 2-pyridinecarboxaldehyde N-oxide (poxal) and its peculiar synthesis requiring oxidation of a-picoline N-oxide by selenium dioxide. Several alternative synthetic routes for poxal have been suggested recently, but with little success, to increase popularity of N-oxide coordination chemistry due to their complicated procedures. We are presenting a simple and efficient two-step synthesis of poxal by employing oxidation of protected 2-pyridinecarboxaldehyde. The details of the synthetic procedure of poxal together with the synthesis and full characterization of copper(II) complexes of its intermediates will be presented.

Popularizing <i>N</i>-oxide coordination chemistry via a novel synthetic approach to the ligand precursor 2-pyridinecarboxaldehyde <i>N</i>-oxide

245th National Meeting (2013)

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Popularizing N-oxide coordination chemistry via a novel synthetic approach to the ligand precursor 2-pyridinecarboxaldehyde N-oxide