There is currently much interest in the absorption, disposition, metabolism, and excretion of polyphenols present in food stuffs in view of their potential health benefits. The structural elucidation of polyphenol glycosides and their conjugated breakdown products in human fluids is still a tedious task due to their low abundance and many potential isomeric forms. Recent technological advances in mass spectrometry (MS) and nuclear magnetic resonance (NMR) have facilitated the more accurate detection of small molecules.1Examples will be provided of the identification of metabolites in complex natural extracts and their colonic catabolites that appear in human body fluids as a consequence of conversions by microbiota in the gastrointestinal tract. Identification and subsequent quantification resulted in cumulative excretion profiles of valerolactone conjugates that display marked inter-personal differences most probably due to variations in colonic microflora.  Related reference:1. Van der Hooft, J. J. J., et al.; Anal. Chem. 2012,  84(16), 7263-7271.

Analytical strategies to a gain deeper insight into dietary polyphenols: Tea as a case study

245th National Meeting (2013)

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