Hydrogen peroxide (H2O2) is one of reactive oxygen species (ROS) and plays a key role as a second messenger in normal cellular signaling.  However, its overexpression leads to oxidative damages to tissues and organs and has been implicated in inflammatory responses and various life-threatening diseases.  Therefore, H2O2 has great potential as a diagnostic and therapeutic biomarker of various inflammatory responses and there is increasing interest in the development of strategies to exploit ROS for diagnostics and therapy.  In this study, we developed fully biodegradable vanillyl alcohol-incorporated copolyoxalate (PVAX) that covalently incorporates vanillyl alcohol and peroxalate linkages in its backbone.  PVAX was designed to react with H2O2 and hydrolytically degrade, leading to H2O2 scavenging and release of therapeutic vanillyl alcohol.  PVAX nanoparticles with 500 nm showed highly potent antioxidant, anti-inflammatory and anti-apoptotic activity in vitro as well as in vivo.

Antioxidant copolyoxalate nanoparticles for the treatment of inflammatory diseases

245th National Meeting (2013)

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