The development of platinum-based drugs was undeniably a remarkable breakthrough in cancer therapy.  However, rapid release of platinum in serum prevents the majority of active species from reaching cancer cells and instead results in many adverse side effects. A better carrier is needed to prevent diminished efficacy due to platinum loss and to enable further therapeutic improvements by utilizing a molecular targeting approach. We are investigating use of a peptide-based metal carrier with unique properties as a linker-less tag for achieving controlled release of platinum upon uptake by tumor cells. Here, we present studies utilizing a series of model peptides to characterize and establish parameters amenable to formation of the peptide-platinum complex involving a broad range of pharmaceutically acceptable additives and solution conditions.  Spectroscopic analyses were used to assess the solubility of peptides containing the metal tag, as well as to monitor the stability of the complex after formation.

Formation, solubility, and stability assessment of a metal-peptide complex

245th National Meeting (2013)

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