The ability to manipulate intracellular transition metal concentrations holds promise both as a tool for elucidating metals' roles in a variety of physiological processes as well as means of treating disease. To these ends, this laboratory has developed (1) stimulus-responsive prochelators to sequester or shuttle cellular copper and (2) triggerable metal �cages� to increase metal concentration selectively.  In order to assess these changes in real time, pro-fluorescent moieties have been introduced into both prochelator and cage structures.  The synthesis, characterization and in cellulo testing of a series of stimulus-responsive metal chelating agents with built-in fluorescence reporting is reported herein.

Development of stimulus-responsive metal chelation with novel fluorescence reporting

245th National Meeting (2013)

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