Particle Replication in Non-wetting Templates (PRINT�) is one of the most versatile techniques in particle fabrication. In this study, we scaled-up PRINT and fabricated hydrogel-based 80 nm x 80 nm x 320 nm particles. We then varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported.

PEGylation density effects on protein binding, macrophage association, biodistribution, and pharmacokinetics

245th National Meeting (2013)

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