Market place demands have dictated that the number and size of field trial studies increase, thus the speed with which the samples are prepared for analysis is under constant scrutiny and must be evaluated. The use of LC in tandem with MS-MS continues to be a powerful tool in the quantitative analysis of small molecules as well as proteins. The much higher selectivity gained with this tool vis-a-vis LC/UV approaches has allowed method development, validation, and analysis times to be dramatically reduced. While the bottleneck of extracted sample analysis has been drastically reduced with these techniques, most residue studies still start with multi-gram samples, requiring large solvent volume extractions; these take a significant amount of time (and cost) to prepare. In our lab, we have been transitioning from 20 gram sample sizes, prepared using traditional extraction methods, down to 100 mg sample sizes prepared using geno-grinders and 96-well plate formats; the main issue is the homogeneity of the sample (and thus sub-sample) selected and extracted. Approaches to extract smaller sample sizes, while using more sophisticated instrumentation have allowed for improvements in precision, sensitivity, and speed of the analysis. Examples of these approaches will be presented.

Development and implementation of high throughput techniques for use in residue and soil dissipation studies

246th National Meeting (2013)

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